Abstracts Archive

Background: Large granular lymphocyte leukemia (LGLL) is a chronic lymphoproliferative disorder characterized by clonal expansion of abnormal cytotoxic T cells or NK cells. While STAT3 mutations occur in 50% of patients, the transcriptional programs driving disease pathogenesis remain incomplet...

KMT2A (MLL1) encodes a histone H3K4 methyltransferase critical for epigenetic activation, but its role in mature T-cell lymphomas (PTCL) remains unclear. We re-analyzed the public dataset GSE58445 (n = 193) to define the transcriptional and clinical correlates of KMT2A expression. Probe-level data w...

Introduction:Mature T-cell lymphomas, including aggressive nodal PTCL, advanced CTCL, and extranodal cytotoxic lymphomas, often have poor outcomes. Cytogenetic abnormalities are common, but their prognostic relevance remains unclear. We evaluated the impact of karyotype (KT) abnormalities, including...

Peripheral T-cell lymphomas are a group of heterogeneous lymphomas arising from mature T-cells. While diverse, these lymphomas often present at advanced stages and carry a poor prognosis. This study aimed to utilize a machine learning model to identify variables most associated with OS using compreh...

Background: Large granular lymphocytic leukemia (LGLL) is characterized by a clonal expansion of cytotoxic CD8+ T or NK cells. The pathogenesis of LGLL is not fully understood, highlighting a need for a deeper understanding of the disease's molecular complexities. Although peripheral blood and hemat...

 Large granular lymphocyte leukemia (LGLL) is a rare lymphoproliferative disorder characterized by clonal expansion of cytotoxic CD8⁺ T cells or NK cells. Somatic activating mutations in STAT3 occur in over 50% of patients, yet their functional consequences remain poorly understood. A major l...

IntroductionWith improved survival in acute myeloid leukemia (AML), second primary malignancies (SPMs) have emerged as significant long-term complications. Unlike relapse, SPMs are distinct malignancies arising from a different clonal origin.The occurrence of T-cell lymphoblastic lymphoma (T-LBL) fo...

Background: Peripheral T-cell lymphomas (PTCLs) comprise < 10% of non-Hodgkin lymphomas with pronounced genomic heterogeneity. The prognostic impact of KMT2A rearrangements in real-world Asian cohorts remains underexplored.Objectives: To define progression-free survival (PFS) and overall survival (O...

Introduction: Although the proportion of T-cell lymphoma(TCL) patients originated from clonal hematopoiesis of indeterminate potential (CHIP) in hematopoietic stem cells, clinical and prognostic significance of CHIP in lymphoma is not systemically analyzed yet. This study aimed to evaluate the ...

IntroductionAngioimmunoblastic T-cell lymphoma (AITL) is a rare, systemic subtype of peripheral T-cell lymphoma characterized by profound immune dysregulation. Its ability to mimic infectious diseases, creates diagnostic challenges that delay treatment, particularly in tuberculosis endemic regions l...